nasal decongestant
Treatment for Cluster Headache
Nasal decongestants like oxymetazoline act as sympathomimetic agents that stimulate α-adrenergic receptors in nasal blood vessels, causing vasoconstriction and reducing mucosal congestion. In cluster headache treatment, they can provide rapid relief by reducing local inflammation and potentially interrupting the trigeminal-autonomic reflex, which contributes to the pathophysiology of the headache.