Nasal medications for Cluster Headache, such as sumatriptan and zolmitriptan nasal sprays, are selective serotonin 5-HT1B/1D receptor agonists that cause vasoconstriction and inhibit neurogenic inflammation. These agents rapidly penetrate the nasal mucosa, providing quick onset of action and providing significant pain relief by modulating trigeminal nerve activity and reducing vascular dilation associated with cluster headache episodes.