Nefopam is a centrally-acting non-opioid analgesic that acts as a multimodal monoamine reuptake inhibitor, primarily blocking the reuptake of serotonin, norepinephrine, and dopamine. In the context of cluster headache treatment, it provides pain relief by modulating neurotransmitter activity in the central nervous system, potentially interrupting the neurogenic inflammatory processes associated with these severe headaches. Its mechanism offers an alternative approach to managing cluster headache pain, particularly in cases where traditional treatments may be less effective.