Neuromodulation for Cluster Headache typically involves electrical stimulation of specific neural targets, such as the hypothalamus or vagus nerve, to alter neural signaling and reduce pain perception. The technique aims to disrupt aberrant neuronal activity and inflammatory pathways associated with cluster headache pathogenesis, potentially by modulating neurotransmitter release and neuroplastic mechanisms. By delivering targeted electrical impulses, neuromodulation can significantly reduce headache frequency, intensity, and duration in treatment-resistant cases.