Nutrition plays a supportive role in managing cluster headaches by modulating inflammatory processes and providing neuroprotective nutrients. Key nutritional interventions may include omega-3 fatty acids, which can reduce neurogenic inflammation, and magnesium, which helps regulate neurotransmitter release and vascular tone, potentially mitigating headache severity and frequency. Strategic nutritional approaches aim to support mitochondrial function, reduce oxidative stress, and potentially modulate the hypothalamic-trigeminal system involved in cluster headache pathogenesis.