oral appliance
Treatment for Cluster Headache
Oral appliances for Cluster Headache typically involve melatonin supplementation, which acts on MT1 and MT2 melatonin receptors to modulate circadian rhythms and reduce neurogenic inflammation. By regulating hypothalamic activity and suppressing sympathetic nervous system hyperexcitability, melatonin can help decrease the frequency and intensity of cluster headache episodes, potentially through its chronobiotic and neuroprotective properties.