Plasma therapy for Cluster Headache involves the administration of high-volume plasma exchange or infusion, which aims to modulate inflammatory processes and neuroimmune responses. By removing pathogenic antibodies, cytokines, and inflammatory mediators from the bloodstream, the treatment potentially reduces neurogenic inflammation and interrupts the neurological mechanisms underlying cluster headache pathogenesis. The primary therapeutic effect is to decrease headache frequency, intensity, and duration by resetting dysregulated immunological and neurological pathways.