polyethylene glycol
Treatment for Cluster Headache
Polyethylene glycol (PEG), when used for cluster headache treatment, acts as an osmotic laxative that potentially modulates the hypothalamic-pituitary-adrenal axis and reduces neurogenic inflammation. Its mechanism involves altering gut microbiome composition and potentially interrupting the inflammatory cascades associated with cluster headache pathogenesis, though the exact neurological pathway is not fully elucidated.