Positional therapy for Cluster Headache involves specific head and body positioning to modulate neural and vascular pathways associated with trigeminal autonomic activation. By altering head and neck positioning, typically involving reclining or adopting a supine position with head elevated or tilted, the therapy aims to reduce sympathetic nervous system stimulation and potentially decrease vascular congestion in the hypothalamic and trigeminal regions implicated in cluster headache pathogenesis.