preventive medication
Treatment for Cluster Headache
Verapamil, a calcium channel blocker, is the first-line preventive medication for cluster headache, acting by modulating neuronal calcium influx and reducing neurovascular inflammation. Its mechanism involves stabilizing neuronal membranes and decreasing sympathetic nervous system activation, which effectively reduces the frequency and intensity of cluster headache episodes. At therapeutic doses (240-960 mg/day), verapamil demonstrates significant prophylactic efficacy with relatively low side effect profiles.