Prolotherapy involves injecting an irritant solution (typically dextrose) into ligamentous and tendinous structures near the trigeminal nerve and cervical region to induce localized inflammation and stimulate healing. The inflammatory response triggers proliferation of fibroblasts and collagen synthesis, potentially modulating neural sensitization and reducing nociceptive signaling associated with cluster headache pathogenesis. By promoting tissue repair and potentially altering neurogenic inflammatory processes, prolotherapy may provide therapeutic benefits for cluster headache management.