Lucent Patient

promethazine

Treatment for Cluster Headache

Promethazine is a first-generation H1 receptor antagonist with antihistaminic and anticholinergic properties that can help manage cluster headache symptoms by reducing nausea, inducing mild sedation, and potentially modulating neurogenic inflammation. Its mechanism of action involves blocking histamine receptors and potentially inhibiting serotonin pathways, which may contribute to its effectiveness in alleviating headache-related symptoms.

3.5

AVERAGE EFFICACY

CASE STUDIES

242

REDDIT COMMENTS

272

REPORTED SIDE EFFECTS

Case Studies

No case studies available.

Reddit Comments

Chrissy6388

4.0

I go to my local urgent care center and they give me phenergan, Benadryl, and toradol in an IV. I also get oxygen. The oxygen is key to treating a cluster headache.

PromethazineAntihistaminesKetorolacOxygen therapy

oh_la_la_92

4.0

A literal bowl of hot coffee, a metric tonne of sugar, a handful of paracetamol and ibuprofen, a cold wet cloth over my eyes and if I can remember it some Phenergan to help knock me out. I will sleep for maybe 3-4 hours and wake up like a brand new h...View more

CaffeineSugarAcetaminophenIbuprofenCold compressPromethazineTopical analgesic

Reported Side Effects

General side effect

CrackedPleasures

4.0

Same, although I have discovered recently that if my eletriptan/Norco combo doesn't work and I am desperate, Promethazine will knock me out for 12 hours and I wake mostly recovered. I call it my "bye bye pill" and it has been a lifesaver since I can'...View more

Promethazine

Reported Side Effects

Drowsiness

TamTaminCrisis

4.0

Get yourself some nausea meds from neuro too! I’ve tried phenergan (works but makes you sleepy.. but that’s awesome if you need to knock yourself out totally), zofran (dissolves under the tongue, tastes pretty okay, like a mint, but for me not as eff...View more

PromethazineZofranMetoclopramide

Reported Side Effects

Drowsiness

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