psychedelic therapy
Treatment for Cluster Headache
Psychedelic substances like psilocybin and LSD act as serotonin 5-HT2A receptor agonists, potentially interrupting the pathological neural circuits associated with cluster headaches. These compounds appear to modulate neurotransmitter systems and induce neuroplastic changes that can provide prophylactic relief and reduce the frequency and intensity of cluster headache episodes through mechanisms not yet fully understood.