Psychological therapies for Cluster Headache primarily target stress reduction and coping mechanisms through cognitive-behavioral techniques and biofeedback, which modulate sympathetic nervous system activity and potentially interrupt the neurogenic inflammatory cascade associated with headache pathogenesis. These interventions aim to decrease autonomic hyperarousal, reduce pain perception, and mitigate the neurological triggers that contribute to the pathophysiology of Cluster Headache, ultimately providing complementary management to pharmacological treatments.