Ramelteon is a selective melatonin receptor agonist (MT1 and MT2) that acts on the suprachiasmatic nucleus, potentially modulating circadian rhythms and sleep-wake cycles. While primarily used for insomnia, some evidence suggests it may have off-label potential in managing cluster headache by influencing neurological pain pathways and circadian dysregulation associated with this condition. Its mechanism of action involves binding to melatonin receptors, which may help reduce headache frequency and intensity through neuromodulatory effects.