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Treatment for Cluster Headache
Sumatriptan, a selective serotonin receptor (5-HT1B/1D) agonist, rapidly alleviates cluster headache symptoms by causing vasoconstriction of intracranial blood vessels and inhibiting pro-inflammatory neuropeptide release. Its subcutaneous or nasal formulations provide fast onset of action, effectively reducing pain intensity and duration by targeting serotonergic pathways in the trigeminal neurovascular system.