sleep modification
Treatment for Cluster Headache
Melatonin acts as a chronobiotic agent that modulates circadian rhythms and potentially interrupts the hypothalamic dysregulation associated with cluster headaches. By binding to melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus, it helps regulate sleep-wake cycles and may reduce the frequency and intensity of cluster headache episodes through neurohormonal modulation.