smoking
Treatment for Cluster Headache
Smoking, specifically high-dose nicotine, acts as a rapid vasoconstrictive agent that reduces cerebral and meningeal blood flow, potentially interrupting the neurovascular inflammatory cascade associated with cluster headaches. The nicotinic acetylcholine receptor agonism leads to immediate sympathetic nervous system stimulation and subsequent reduction in pain signaling and vascular dilation, providing acute relief for cluster headache sufferers.