Social support acts as a non-pharmacological intervention for Cluster Headache by modulating stress-related neurobiological pathways, potentially reducing hypothalamic activation and sympathetic nervous system arousal that can trigger or exacerbate headache episodes. Through emotional buffering and psychological coping mechanisms, social support can lower cortisol levels, decrease inflammatory markers, and enhance pain resilience, thereby indirectly mitigating the frequency and intensity of Cluster Headache attacks.