Spiritual practice may modulate neural pathways and neurotransmitter systems through meditation and mindfulness techniques, potentially reducing the neurogenic inflammation and autonomic dysregulation associated with Cluster Headaches. By activating parasympathetic pathways and decreasing sympathetic nervous system activation, these practices can potentially lower pain perception, reduce neuroinflammatory markers, and promote neuroplastic changes that may mitigate the frequency and intensity of Cluster Headache episodes.