Strength training for Cluster Headache potentially modulates neurological pain pathways through neuromuscular adaptations and hormonal responses, with a primary mechanism involving increased endogenous β-endorphin and serotonin release that can attenuate pain perception and neurogenic inflammation. The physical exertion and associated neuroendocrine changes may help regulate hypothalamic function and reduce the frequency and intensity of cluster headache episodes by influencing autonomic nervous system balance and pain modulation circuits.