Stress management techniques for Cluster Headache primarily modulate the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol and sympathetic nervous system activation. By employing strategies such as cognitive-behavioral therapy, relaxation techniques, and mindfulness, these interventions decrease neurogenic inflammation and autonomic dysregulation associated with cluster headache pathogenesis. The primary effects include reduced neuronal excitability, decreased neuroinflammatory responses, and improved pain threshold regulation.