supplement cessation
Treatment for Cluster Headache
Melatonin, a neurohormone involved in circadian rhythm regulation, has shown efficacy in reducing cluster headache frequency and intensity by modulating hypothalamic and neurotransmitter pathways. Upon cessation, patients may experience a potential rebound effect with temporary increased headache susceptibility, as the neurological and circadian regulatory mechanisms readjust to endogenous melatonin production.