Testosterone, when used for Cluster Headache, acts as a potential therapeutic agent by modulating hypothalamic function and neurotransmitter pathways. Its primary mechanism involves reducing neurogenic inflammation and potentially regulating the hypothalamic-pituitary-gonadal axis, which may help decrease the frequency and intensity of cluster headache episodes. The treatment leverages testosterone's neuroendocrine effects to potentially interrupt the pathophysiological mechanisms underlying cluster headache pathogenesis.