Lucent Patient

tizanidine

Treatment for Cluster Headache

Tizanidine is an α2-adrenergic agonist that acts as a central muscle relaxant, which may provide therapeutic benefit in Cluster Headache by modulating sympathetic nervous system activity and reducing neurogenic inflammation. Its mechanism involves inhibiting excitatory neurotransmitter release and decreasing muscle tone, potentially interrupting the neurological cascade associated with cluster headache pathogenesis.

3.3

AVERAGE EFFICACY

CASE STUDIES

142

REDDIT COMMENTS

157

REPORTED SIDE EFFECTS

Case Studies

No case studies available.

Reddit Comments

AL309

4.0

Things that have worked for me include steroids (prednisone taper) will only give about three weeks of relief and fairly cheap for the uninsured, verapamil - this is the gold standard also cheap, topiramate (topamax) side effects suck but will stop t...View more

PrednisoneVerapamilAntiepilepticsTizanidineIbuprofen

spoonerxix19

4.0

I also have a pituitary "lesion". My endocrinologist said that most people do and he didn't feel it was related to hemicrania continua. He said if he did he would say lets take it out but it isn't that. I am ADHD and have been considering Adderall. I...View more

LamotrigineTizanidineTricyclic antidepressantsAleveNerve blocksCefalyGammacoreMelatoninCaffeineAlcoholSugar

Reported Side Effects

Weight gainDental problemsRebound headache

spoonerxix19

4.0

I think a professional diagnosis would be far more useful. There are many types of CH that respond to different treatments. Another MAJOR disadvantage is that normal doctors and clinics think you are trying to score pain pills they have even told me ...View more

AnticonvulsantsLidocaineMagnesiumTricyclic antidepressantsMelatoninTizanidineNeurostimulationNerve stimulationDietary modificationAlcohol

Reported Side Effects

Pain

thevoodooclam

5.0

Yep, this is exactly where my migraine pain starts, always. It then sometimes moves to other areas of the head. As others said, it’s occipital. Here is why helped me decrease occipital migraine days from 20+ a month to 2 a month: 1. Botox every 12 ...View more

BotoxNerve blocksStretchingPositioningTizanidineCgrp antagonistNsaidsAntihistaminesOndansetronHeat therapyCold therapy

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