Lucent Patient

trazodone

Treatment for Cluster Headache

Trazodone, primarily an antidepressant with serotonin antagonist and reuptake inhibitor (SARI) properties, has been used off-label for Cluster Headache management due to its potential to modulate serotonergic pathways and provide analgesic effects. By antagonizing 5-HT2A receptors and inhibiting serotonin reuptake, trazodone may help reduce the frequency and intensity of cluster headache episodes, though its precise mechanism in this context is not fully elucidated.

3.0

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

REPORTED SIDE EFFECTS

Case Studies

No case studies available.

Reddit Comments

GeneralSet5552

5.0

When i was 1st diagnosed with Chronic Cluster HA It was in 1983. The doctor wanted me to take lithium so I agreed but I changed my mind after a few weeks. Than in 1987 I was diagnosed with Bipolar & UI was a rapid cycler with several mood swings a ...View more

Calcium channel blockersTrazodoneDuloxetineAntipsychotics

Reported Side Effects

None

kimchijihye

4.0

Coke, fries and coffee are like, ngl, the first line of offense against migraines. I have used a large punch bowl with ice and ice water for migraines. 10-15 seconds with my face/head submerged. I’m colder, wetter and slightly miserable, but my mi...View more

CaffeineCold therapyIce therapyAntihistaminesTrazodoneContact lensesHormonal contraceptionTirzepatide

Reported Side Effects

Cold sensationWetnessMood changes

DikaCato

4.0

i failed about 15 meds in various combinations before finding Propranalol ER 60mg. Here is my whole regimen: AM: 60mg propranolol ER, 10mg baclofen PM: 50mg trazodone, 10mg baclofen, 40mg prozac Monthly: Ajovy injection Triptans: Zolmitriptan fo...View more

Beta blockersBaclofenTrazodoneSsrisMonoclonal antibodiesTriptanTriptansPhysical therapy

pinkmigraine

4.0

Or try Tizanidine. It is a short-acting muscle relaxer. I find it is great for helping me get to sleep at night. I also have trazodone to help me stay asleep (insomnia is horrible during a migraine). I dont take them everyday, just as needed. The...View more

TizanidineTrazodone

Reported Side Effects

General side effect

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