Lucent Patient

tricyclic antidepressants

Treatment for Cluster Headache

Tricyclic antidepressants, such as amitriptyline, modulate pain perception by inhibiting serotonin and norepinephrine reuptake in the central nervous system, which can reduce the frequency and intensity of cluster headaches. Their mechanism involves central pain modulation and potential sympathetic nervous system effects, with secondary benefits of improving sleep patterns and reducing neurogenic inflammation.

3.2

AVERAGE EFFICACY

CASE STUDIES

358

REDDIT COMMENTS

547

REPORTED SIDE EFFECTS

Case Studies

No case studies available.

Reddit Comments

AccomplishedDust974

3.0

Try CGRPs (ubrelvy, zavzpret), Botox, im on nortriptyline to help every day migraines and it has helped and ubrelvy to stop a migraine and have used both CGRPs mentioned above for a cluster attack. It worked 1/2x

GepantTricyclic antidepressants

heyy_kayb

2.0

## Trying to see if anyone else has experienced what I’m experiencing.. I’ve been having these headaches since Feb. 4th and I’m not sure if I’m experiencing shadow headaches … Okay so my headaches have been going on since Feb.4th every single day… th...View more

Tricyclic antidepressantsCalcium channel blockers

extacy1375

1.0

Are you me?...lol Most of the stuff you wrote, I am with. No hospital visits (DAM close though) Original diagnosis for me was TAC/SUNCT. 2 CAT scans and a MRI of head were unremarkable. My meds issued from start to current--- Topamax - Did no...View more

AntiepilepticsTriptansTricyclic antidepressantsAmitriptylineNsaidsVitamin dPsychedelics

Reported Side Effects

Gastrointestinal problemsDrowsinessSexual dysfunctionHeadache

No_Respond4621

3.0

## Cluster Headaches in NZ Kia Ora, I'm (26f) in NZ and have been experiencing cluster headaches since I was 19. I finally saw a neurologist about them last year and have been prescribed a pretty intense medication regimen for when the cycle starts u...View more

SumatriptanTricyclic antidepressantsVerapamilPrednisoneMelatonin

Reported Side Effects

Injection difficulties

...