Vaccines for Cluster Headache primarily focus on modulating immune response and reducing neurogenic inflammation through targeted antibody production. By stimulating the immune system to generate specific antibodies against inflammatory mediators like CGRP (Calcitonin Gene-Related Peptide) or other neuroinflammatory factors, these vaccines aim to decrease the frequency, intensity, and duration of cluster headache episodes. The mechanism involves inducing a controlled immune response that helps mitigate the underlying neurological and vascular mechanisms contributing to cluster headache pathogenesis.