Lucent Patient

valproate

Treatment for Cluster Headache

Valproate acts as a broad-spectrum antiepileptic drug that modulates neuronal excitability by enhancing GABA neurotransmission and inhibiting voltage-gated sodium channels. In cluster headache treatment, it is believed to stabilize neuronal membranes and reduce neurogenic inflammation, potentially decreasing the frequency and intensity of headache attacks. Its mechanism involves suppressing neuronal hyperexcitability in the trigeminovascular system, which is thought to be a key pathophysiological mechanism in cluster headache.

4.3

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

REPORTED SIDE EFFECTS

Case Studies

Significance of Migrainous Features in Cluster Headache: Divalproex Responsiveness

5.0

Two patients with cluster headache exhibiting prominent migrainous features, refractory to standard cluster headache treatments and surgical interventions, achieved remission upon treatment with divalproex.

valproate

Coexistence of cluster headache and paroxysmal hemicrania: does it exist? A case report and literature review

5.0

This case study reports a 22-year-old male with simultaneous cluster headache and chronic paroxysmal hemicrania who responded completely to indomethacin treatment, with a literature review of similar coexisting cases.

indomethacinacetaminophennaproxentriptansrizatriptanamitriptylinecalcium channel blockersvalproatebeta blockers

Cluster-status migrainosus with a weekly periodicity responsive to high-flow oxygen: A case report

4.0

A 54-year-old female presented with a unique pattern of cluster headaches that evolved into status migrainosus, which was successfully treated with high-flow 100% oxygen after multiple other treatments failed.

beta blockersvalproateantiepilepticsamitriptylinegabapentinanticonvulsantstriptansbutalbitaloxygen therapy

This case study reports a 22-year-old male with simultaneous cluster headache and chronic paroxysmal hemicrania, both types of attacks responding to indomethacin treatment. The study also reviews literature on the coexistence of these two trigeminal autonomic cephalalgias.

5.0

indomethacinacetaminophennaproxentriptansrizatriptanamitriptylinecalcium channel blockersvalproatebeta blockersh2 blocker

Reddit Comments

Miserable-Ninja2066

5.0

I have both also. Lamotrigine got rid of CH and I was chronic for years. Had to switch to lithium temporarily and that worked too. Now I'm on depakote. I did get a brief relapse in CH a couple weeks ago but then when I did blood work to check depakot...View more

AnticonvulsantsLithiumValproate

Reported Side Effects

None

Emotional-Ant3953

4.0

I've been on lithium and depakote with no results. At least the o2 works so well for me.

ValproateOxygen therapy

OkDog873

5.0

I was taking D3 10000IU daily. Neurologist gave me a 50,000IU once a week. My clusters are under control thank God. He also gave me depakote and sumatriptan rescue. I took the depakote for a while by itself and it did nothing. The sumatriptan wo...View more

Vitamin dValproateTriptans

TheCazzedAnmol

3.0

My headache doctor has prescribed verapamil,sodium valporate and topiramate to me so far and they have somehow reduced the frequency of attacks but I still have atleast one daily for the past 2 years. I was injected with GonBlock 9 times before I dev...View more

Calcium channel blockersValproateAntiepilepticsNerve blocksVitamin d

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