High-dose vitamin supplementation, particularly vitamin D3 and riboflavin (vitamin B2), may modulate neurological inflammation and mitochondrial function in cluster headache patients. These vitamins potentially reduce neurogenic inflammation, improve cellular energy metabolism, and may help regulate neurotransmitter pathways involved in pain perception and headache pathogenesis. The mechanism involves antioxidant properties, mitochondrial support, and potential neuromodulatory effects that can help reduce headache frequency and intensity.