Zavzpret (zavegepant) is a calcitonin gene-related peptide (CGRP) receptor antagonist that blocks CGRP-mediated vasodilation and neurogenic inflammation associated with cluster headaches. By competitively inhibiting the CGRP receptor, it prevents the neuroinflammatory cascade that contributes to headache pathophysiology, thereby providing acute relief for patients experiencing cluster headache attacks. Its targeted mechanism offers a novel approach to managing this severe form of headache with potentially fewer systemic side effects compared to traditional treatments.