Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), may modulate neural hyperexcitability and reduce cortical hyperactivity associated with Visual Snow Syndrome by enhancing serotonergic neurotransmission and potentially stabilizing neuronal membrane potentials. These medications can help mitigate symptoms by regulating neural circuit dysfunction and potentially reducing aberrant sensory processing through alterations in neurotransmitter signaling.