Benzodiazepines act on GABA-A receptors, enhancing inhibitory neurotransmission and producing anxiolytic and sedative effects that can help modulate the heightened neural anxiety and dissociative symptoms associated with Depersonalization-derealization disorder. By potentiating GABA's inhibitory action, these medications can reduce the hyperarousal and emotional dysregulation characteristic of DPDR, potentially alleviating the disorder's core phenomenological experiences.