Depersonalization-derealization disorder (DPDR) Treatments

BC007 is a novel autoantibody-neutralizing drug that targets G-protein-coupled receptor autoantibodies, potentially disrupting pathological neurological processes associated with Depersonalization-de...

Probiotics, particularly strains that modulate the gut-brain axis, may help manage DPDR by reducing neuroinflammation and improving neurotransmitter balance through interactions with the microbiome-g...

Albendazole, primarily an anthelmintic agent, has been investigated for potential off-label use in Depersonalization-derealization disorder (DPDR) due to its proposed immunomodulatory and anti-inflam...

Ivermectin is an antiparasitic medication that may potentially modulate neurological symptoms through its action on GABA receptors and glutamate signaling pathways. While not a primary treatment for ...

Certain supplements like omega-3 fatty acids and N-acetylcysteine (NAC) may help modulate glutamatergic and dopaminergic neurotransmission, potentially reducing DPDR symptoms by stabilizing neural ci...

Selective serotonin reuptake inhibitors (SSRIs) are commonly used in DPDR treatment, primarily targeting serotonin neurotransmission to modulate emotional processing and reduce symptoms. By increasin...

Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological intervention for Depersonalization-derealization disorder, targeting serotonergic dysfunction by increasing synaptic se...

SSRIs modulate serotonergic neurotransmission by inhibiting serotonin reuptake, potentially reducing symptoms of DPDR by normalizing neural circuit dysfunction and alleviating underlying anxiety and ...

Antipsychotics used in DPDR primarily modulate dopaminergic and serotonergic neurotransmission, targeting disrupted neural circuits associated with self-perception and reality processing. By blocking...

Lamotrigine is an anticonvulsant and mood stabilizer that modulates glutamatergic neurotransmission by blocking voltage-gated sodium channels, which reduces excessive neuronal excitability and potent...

Exercise acts as a non-pharmacological intervention for DPDR by modulating neurotransmitter systems, particularly increasing serotonin, dopamine, and norepinephrine levels, which can help regulate em...

Carbamazepine, an anticonvulsant and mood stabilizer, modulates neuronal excitability by blocking voltage-gated sodium channels and reducing glutamatergic neurotransmission. In Depersonalization-dere...

SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) modulate neurotransmitter activity by blocking the reuptake of serotonin and norepinephrine, potentially alleviating DPDR symptoms through enhance...

While no specific diet is FDA-approved for treating Depersonalization-derealization disorder (DPDR), dietary interventions may help modulate neurotransmitter function and reduce symptoms by stabilizi...

Benzodiazepines act on GABA-A receptors, enhancing inhibitory neurotransmission and producing anxiolytic and sedative effects that can help modulate the heightened neural anxiety and dissociative sym...

Opioid antagonists such as naltrexone act by blocking µ-opioid receptors, potentially modulating the dysregulated endogenous opioid system implicated in DPDR pathophysiology. By competitively inhibit...

Tricyclic antidepressants (TCAs) modulate neurotransmitter activity by inhibiting serotonin and norepinephrine reuptake, potentially alleviating the emotional dysregulation and anxiety associated wit...

Meditation in DPDR primarily modulates the default mode network (DMN) and reduces hyperactivity in the limbic system, promoting neuroplastic changes that can decrease anxiety and dissociative symptom...

Breathing exercises modulate the autonomic nervous system by activating the parasympathetic response, which reduces sympathetic hyperarousal and cortical hypervigilance associated with DPDR. These te...

Yoga acts as a non-pharmacological intervention for Depersonalization-derealization disorder by modulating the autonomic nervous system and reducing sympathetic hyperarousal through mindfulness, cont...

Grounding techniques in DPDR primarily modulate the autonomic nervous system through sensory stimulation, activating the parasympathetic response and reducing hyperarousal in the limbic and prefronta...

Psychedelics like psilocybin and LSD act primarily on 5-HT2A serotonin receptors, modulating neural connectivity and potentially disrupting rigid default mode network patterns associated with DPDR. T...

Ketamine, when used in controlled clinical settings, acts as an NMDA receptor antagonist and shows potential in rapidly alleviating symptoms of Depersonalization-derealization disorder by modulating ...

Sleep plays a crucial neurobiological role in modulating the dysregulated neural networks associated with Depersonalization-derealization disorder, potentially restoring cortical connectivity and red...

Stimulants like methylphenidate or amphetamines can modulate dopaminergic and noradrenergic neurotransmission, potentially helping to restore sensory integration and reduce the detachment symptoms of...