Exercise acts as a non-pharmacological intervention for DPDR by modulating neurotransmitter systems, particularly increasing serotonin, dopamine, and norepinephrine levels, which can help regulate emotional processing and reduce anxiety. Physical activity also promotes neuroplasticity, reduces stress hormones like cortisol, and enhances overall brain connectivity, potentially alleviating the dissociative symptoms associated with DPDR by grounding individuals in their physical experience and improving cognitive-emotional regulation.