Lamotrigine is an anticonvulsant and mood stabilizer that modulates glutamatergic neurotransmission by blocking voltage-gated sodium channels, which reduces excessive neuronal excitability and potentially ameliorates the dissociative symptoms of DPDR. By stabilizing neuronal membranes and potentially normalizing aberrant cortical activity, lamotrigine may help mitigate the depersonalization and derealization experiences characteristic of the disorder.