Probiotics, particularly strains that modulate the gut-brain axis, may help manage DPDR by reducing neuroinflammation and improving neurotransmitter balance through interactions with the microbiome-gut-brain pathway. By potentially enhancing serotonin production, reducing cortisol levels, and mitigating systemic inflammation, probiotics can indirectly support neurological stabilization and potentially alleviate dissociative symptoms associated with DPDR.