Sleep plays a crucial neurobiological role in modulating the dysregulated neural networks associated with Depersonalization-derealization disorder, potentially restoring cortical connectivity and reducing hyperarousal in the default mode network. During sleep, particularly during slow-wave and REM stages, the brain undergoes synaptic renormalization and emotional processing that may help recalibrate disrupted neurological patterns underlying DPDR symptoms, potentially alleviating perceptual distortions and emotional detachment.