Lucent Patient

ssris

Treatment for Depersonalization-derealization disorder (DPDR)

SSRIs modulate serotonergic neurotransmission by inhibiting serotonin reuptake, potentially reducing symptoms of DPDR by normalizing neural circuit dysfunction and alleviating underlying anxiety and depressive comorbidities. While the exact mechanism in DPDR is not fully understood, SSRIs may help restore disrupted neural connectivity and emotional processing, providing symptomatic relief through their anxiolytic and mood-stabilizing properties.

3.3

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

REPORTED SIDE EFFECTS

Case Studies

Lamotrigine + SSRI cured my drug-induced DPDR

5.0

A forum post describing recovery from drug-induced depersonalization-derealization disorder using a combination of lamotrigine and an SSRI (sertraline).

lamotriginessris

The 5 Best Medications for Depersonalization (DPDR) - Depersonalization & Derealization

3.0

This case study reviews five medications that may help treat Depersonalization-Derealization Disorder (DPDR), discussing their mechanisms of action and clinical evidence based on various studies and trials.

opioid antagonistslamotriginessrisbenzodiazepinestricyclic antidepressants

Understanding Depersonalization and Derealization Disorder | Insights from Paul Molyneux and Dr. Puder — Psychiatry & Psychotherapy Podcast

2.0

This case study examines various pharmacological treatments for depersonalization-derealization disorder (DPDR), a dissociative condition where patients feel detached from themselves or reality, through a comprehensive review of existing research and treatment outcomes.

ssrislamotriginetricyclic antidepressantsopioid antagonistsbenzodiazepinesantipsychoticsstimulantstherapy

Symptom profile and diagnostic utility of depersonalization–derealization disorder: A retrospective critical review from India

3.0

A retrospective 10-year study of 14 patients diagnosed with Depersonalization-derealization disorder (DPDR) in India, examining diagnosis frequency, symptoms, and treatment patterns at a tertiary psychiatry institute.

ssrissnrisantipsychoticslamotriginecarbamazepineopioid antagonists

Reddit Comments

Mikecrete

4.0

Dude i understand what you are going through. We have very similar experiences. I will tell you what helped me alot. I am not cured but i am alot better. 1: Affirmations. I repeat positive phrases whenever i feel scared,anxious or weird. 2: CBD oil...View more

Positive affirmationsCannabisExerciseMeditationSsris

None

4.0

I've seen these three gurus you speak of, my only question for them is - if I'm supposed to get on with my life and not overthink DP/DR, then why would I buy the friggin book and read and obsess even more about these disorders? I usually do just what...View more

SsrisBenzodiazepinesExerciseMindfulness