Lucent Patient

stimulants

Treatment for Depersonalization-derealization disorder (DPDR)

Stimulants like methylphenidate or amphetamines can modulate dopaminergic and noradrenergic neurotransmission, potentially helping to restore sensory integration and reduce the detachment symptoms of DPDR. By enhancing neural connectivity and arousal in prefrontal and limbic circuits, these medications may improve cognitive processing and reduce the dissociative experience, though their use is considered off-label and requires careful clinical management.

2.0

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

REPORTED SIDE EFFECTS

Case Studies

Understanding Depersonalization and Derealization Disorder | Insights from Paul Molyneux and Dr. Puder — Psychiatry & Psychotherapy Podcast

2.0

This case study examines various pharmacological treatments for depersonalization-derealization disorder (DPDR), a dissociative condition where patients feel detached from themselves or reality, through a comprehensive review of existing research and treatment outcomes.

ssrislamotriginetricyclic antidepressantsopioid antagonistsbenzodiazepinesantipsychoticsstimulantstherapy

Methylphenidate as a Treatment for Depersonalization/Derealization Disorder

2.0

This study investigated methylphenidate (Ritalin) as a potential treatment for depersonalization/derealization disorder (DPDR) in adults with ADHD, finding complex results where the medication may help some individuals but worsen symptoms in others with higher anxiety or ADHD severity.

stimulants

Reddit Comments

Background-Mikeyboy

2.0

I’ve had dpdr for 10 plus years in the beginning it was debilitating now so it’s manageable but recently I was told I had adhd as well. Tried medication bc I’m desperate at this point and while I did feel more focused I felt so irritable which doc sa...View more

Stimulants

Reported Side Effects

Irritability