Certain supplements like omega-3 fatty acids and N-acetylcysteine (NAC) may help modulate glutamatergic and dopaminergic neurotransmission, potentially reducing DPDR symptoms by stabilizing neural circuits and mitigating neuroinflammatory processes. While research is limited, these supplements are thought to support neuroplasticity and potentially ameliorate the dissociative experiences characteristic of DPDR through their neuroprotective and neurotransmitter-regulating properties.